Year: 2014
Type: book-chapter
Abstract: Color Plate 1 (chapter 1).Schematic structure of particles of members of the order Nidovirales.E, envelope protein; GP and gp, glycoprotein; M, membrane protein; N, nucleoprotein; S, spike glycoprotein.The HEs of some group 2 coronaviruses and some toroviruses are not illustrated.The stoichiometry of the virion components is shown arbitrarily.Adapted from reference 44a.Color Plate 2 (chapter 1).Models for nidovirus replication and transcription using hypothetical viruses that produce four subgenomic mRNAs.Plus-strand RNA is depicted in red, and minus-strand RNA is depicted in blue.In the case of coronaviruses and arteriviruses, discontinuous extension during minus-strand RNA synthesis is proposed as the mechanism to produce subgenome-length minus-strand templates.The RTC is proposed to be attenuated at one of the body TRSs in the 3Ј-proximal part of the genome, after which the nascent minus strand would be extended with the antileader sequence by a process of discontinuous extension.The completed subgenome-length minus strands would serve as templates for mRNA synthesis.In the case of roniviruses and all but the largest subgenome-length mRNA of toroviruses, conserved attenuation sequences, found upstream of each of the genes in the 3Ј-proximal part of the genome, direct the termination of nascent minus-strand synthesis.The attenuated subgenome-length minus-strand RNAs would serve directly as templates for transcription of mRNA.Adapted from reference 37.
Source: ASM Press eBooks
Language: Spanish
Subfield: Animal Science and Zoology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4232704995