Work

Histone tails promote PARP1-dependent structural rearrangements in nucleosomes

Year: 2019

Type: article

Abstract: PARP1 alters the wrapping of nucleosomal DNA on the surface of the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here we show that non-structured histone tails participate in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.

Source: Доклады Академии наук

DOI: 10.31857/s0869-56524893318-320

Authors: N. V. Maluchenko, D. S. Sultanov, E. Yu. Kotova, M. P. Kirpichnikov, V. M. Studitsky, A. V. Feofanov

Institutions: Lomonosov Moscow State University, Fox Chase Cancer Center, Russian Academy of Sciences, Institute of Bioorganic Chemistry

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W4232730099

FWCI:

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