Work

Drug retention, efflux, and resistance in tumor cells

Year: 1997

Type: article

Abstract: Multiple drug resistance (MDR) in tumor cells has been related to the expression of transport proteins which alter cellular drug transport and distribution. Three different genes (mdr, MRP, and LRP) and their products have been implicated in MDR. Several fluorescent dyes have been used to monitor the effect of these transport proteins on drug retention, as well as for screening of drugs which block drug efflux and thus enhance cellular drug retention and cytotoxicity. The present review summarizes current knowledge about MDR phenotypic markers and techniques available for study of MDR by flow cytometry.

Source: Cytometry

DOI: 10.1002/(sici)1097-0320(19971201)29:4<279::aid-cyto3>3.0.co;2-5

Authors: Awtar Krishan, Catherine Morgan Fitz, Ilia Andritsch

Institutions: University of Miami, Sylvester Comprehensive Cancer Center

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute