Work

Estimating the Extent of the Health Hazard Posed by High-Production Volume Chemicals

Year: 2001

Type: article

Abstract: We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.

Source: Environmental Health Perspectives

DOI: 10.1289/ehp.01109953

Authors: A R Cunningham, H S Rosenkranz

Institution: University of Pittsburgh

Language: English

Topic: Carcinogens and Genotoxicity Assessment

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500