Efficacy and Tolerability of the New Antiepileptic Drugs, I: Treatment of New‐Onset Epilepsy: Report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
Year: 2004
Type: article
Abstract: PURPOSE: To assess the evidence demonstrating efficacy, tolerability, and safety of seven new antiepileptic drugs [AEDs; gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), oxcarbazepine (OXC), levetiracetam (LEV), and zonisamide (ZNS), reviewed in the order in which these agents received approval by the U.S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies. METHODS: A 23-member committee, including general neurologists, pediatric neurologists, epileptologists, and doctors in pharmacy, evaluated the available evidence based on a structured literature review including MEDLINE, Current Contents, and Cochrane Library for relevant articles from 1987 until September 2002, with selected manual searches up to 2003. RESULTS: Evidence exists, either from comparative or dose-controlled trials, that GBP, LTG, TPM, and OXC have efficacy as monotherapy in newly diagnosed adolescents and adults with either partial or mixed seizure disorders. Evidence also shows that LTG is effective for newly diagnosed absence seizures in children. Evidence for effectiveness of the new AEDs in newly diagnosed patients with other generalized epilepsy syndromes is lacking. CONCLUSIONS: The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with newly diagnosed epilepsy and identify those seizure types and syndromes for which more evidence is necessary.
Source: Epilepsia
Authors: Jacqueline A. French, Andres M. Kanner, Jocelyn Bautista, Bassel Abou‐Khalil, Thomas Browne, Cynthia L. Harden, William H. Theodore, Carl Bazil, John Stern, Steven C. Schachter, Donna Bergen, Deborah Hirtz, Georgia D. Montouris, Mark Nespeca, Barry Gidal, William J. Marks, William R. Turk, James H. Fischer, Blaise Bourgeois, Andrew Wilner, R. Edward Faught, Rajesh C. Sachdeo, Ahmad Beydoun, Tracy A. Glauser
Institutions: Hospital of the University of Pennsylvania, University of Pennsylvania, Rush University Medical Center, Rush University, Cleveland Clinic, Vanderbilt University Medical Center, Boston University, Boston Medical Center, Cornell University, Weill Cornell Medicine, National Institutes of Health, National Institute of Neurological Disorders and Stroke, NewYork–Presbyterian Hospital, Columbia University Irving Medical Center, Beth Israel Deaconess Medical Center, Harvard University, Rady Children's Hospital-San Diego, University of Wisconsin–Madison, UW Health University Hospital, University of California, San Francisco, University of California San Francisco Medical Center, Nemours Children's Clinic, University of Illinois Chicago, Boston Children's Hospital, University of Alabama, University of Alabama at Birmingham, UAB Medicine, University of Medicine and Dentistry of New Jersey, University of Michigan, Cincinnati Children's Hospital Medical Center
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4233356841