Faculty Opinions recommendation of Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells.
Year: 2019
Type: peer-review
Abstract: Umbilical cord blood (CB)-derived hematopoietic stem cells (HSCs) are essential in many life saving regenerative therapies, but their low number in CB units has significantly restricted their clinical use despite the advantages they provide during transplantation 1 .Select small molecules that enhance hematopoietic stem and progenitor cell (HSPC) expansion in culture have been identified 2,3 , however, in many cases their mechanisms of action or the nature of the pathways they impinge on are poorly understood.A greater understanding of the molecular pathways that underpin the unique human HSC self-renewal program will facilitate the development of targeted strategies that expand these critical cell types for regenerative therapies.Whereas transcription factor networks have been shown to influence the self-renewal and lineage decisions of human HSCs 4,5 , the post-transcriptional mechanisms guiding HSC fate have not been closelyUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/
Author: Hal Broxmeyer
Institution: Indiana University School of Medicine
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G4564650672
OpenAlex ID: W4233692169