Year: 2018
Type: article
Abstract: Voltage‐gated Ca2+ (CaV) channels mediate Ca2+ entry into excitable cells to regulate a myriad of cellular events following membrane depolarization. We report the engineering of RGK GTPases, a class of genetically encoded CaV channel modulators, to enable photo‐tunable modulation of CaV channel activity in excitable mammalian cells. This optogenetic tool (designated optoRGK) tailored for CaV channels could find broad applications in interrogating a wide range of CaV‐mediated physiological processes.
Source: Angewandte Chemie
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,790
Funders: American Cancer Society, Welch Foundation, Cancer Prevention and Research Institute of Texas, National Natural Science Foundation of China, Recruitment Program for Young Professionals, National Institutes of Health, Fundamental Research Funds for the Central Universities, National Institute of General Medical Sciences
Awards: G1160346110, G1671227980, Optogenetic toolkit for remote control of voltage-gated calcium channels, G2393929632, G4341254421, Optogenetic Toolkit for Precise Epigenome Editing in Cancer Cells, Recruitment of First-Time, Tenure-Track Faculty Members, G5578305360, MOLECULAR CONTROL OF CALCIUM INFLUX AT THE ER-PLASMA MEMBRANE JUNCTIONS, G8688773675, G8692009690
OpenAlex ID: W4233917112