Correction: Wdr62 is involved in female meiotic initiation via activating JNK signaling and associated with POI in humans
Year: 2019
Type: erratum
Abstract: The authors originally reported that infertility in Wdr62-deficient mice was caused by defects in meiotic initiation, as presented and analyzed in embryonic ovaries and early (P3 and P5) postnatal testes. However, the original article did not include the finding that in older (21 days and later) male animals, meiotic initiation proceeds normally for second wave spermatogenesis, and that male germ cells in older mice exhibit metaphase I arrest. The mechanism of metaphase I arrest in older male germ cells, and the basis of the difference in Wdr62 dependency in young and older male germ cells is currently under investigation.
Source: PLoS Genetics
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,350
OpenAlex ID: W4234231544