Cognitive Phenotypes, Brain Morphometry and the Detection of Cognitive Decline in Preclinical AD
Year: 2009
Type: article
Abstract: Identifying a preclinical phase of Alzheimer's Disease (PCAD) that is distinct from cognitive changes in healthy aging continues to be a major research focus. Combining neuropsychological and neuroimaging methodologies should improve our ability to differentiate healthy from pathological aging, although studies that utilize both methods often result in equivocal findings, possibly due to variability in cognitive test performance that may be capturing distinct phenotypes. One method of capturing this cognitive variability is to utilize contrasting neuropsychological tests to identify subgroups representative of distinct cognitive phenotypes, and determine whether differences in brain morphometry support these classifications. We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia.
Source: Behavioural Neurology
DOI: 10.1155/2009/617312
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,790
Funders: Foundation for the National Institutes of Health, U.S. Department of Veterans Affairs, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Alzheimer's Disease Neuroimaging Initiative, Novartis Pharmaceuticals Corporation, Northern California Institute for Research and Education, Elan, Eisai, National Institutes of Health, U.S. Food and Drug Administration, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: G104586243, G1923530831, G2152643862, G2835601961, Morphometry Biomedical Informatics Research Network, G29951154, G3131374986, G3146424788, G3553156159, G3705772492, G3710456697, G43180419, G5207404921, G5209990037, G5389965057, The VETSA Longitudinal MRI Twin Study of Aging, Structure and Functional Imaging of Age-Related Changes in Working Memory, G5605366547, G5678256514, Alzheimer's Disease Neuroimaging Initiative, G613619302, G6161276258, G6259281481, G6899163935, G6957926738, G7414321945, G7799614282, G781725486, Alzheimer's Disease Cooperative Study, G839208290, The VETSA longitudinal twin study of cognition and aging, G9000039018, G9000122335, G920654007
OpenAlex ID: W4234317510