Work

Exploration of alternative scaffolds for P2Y14 receptor antagonists containing a biaryl core

Year: 2020

Type: other

Abstract: Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl antagonists of the P2Y14 receptor (P2Y14R) were synthesized and tested for affinity in P2Y14R-expressing CHO cells by flow cytometry. Given this series’ low water solubility, various polyethylene glycol derivatives of a distally binding piperidin-4-yl moiety of moderate

DOI: 10.1021/scimeetings.0c03880

Authors: Young-Hwan Jung, Jinha Yu, Zhiwei Wen, Veronica Salmaso, Tadeusz Karcz, Ngan B. Phung, Sierra Duca, John M. Bennett, Steven Dudas, Zhan-Guo Gao, Donald N. Cook, Kenneth A. Jacobson

Language: English

Topic: Adenosine and Purinergic Signaling

Subfield: Physiology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4234359452

Cites:

Cited by:

Related to: 10