Poly(oligonucleotide)
Year: 2014
Type: article
Abstract: Here we report the preparation of poly(oligonucleotide) brush polymers and amphiphilic brush copolymers from nucleic acid monomers via graft-through polymerization. We describe the polymerization of PNA-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polymerization (ROMP) with the initiator, (IMesH2)(C5H5N)2(Cl)2RuCHPh.1 In addition, we present the preparation of poly-PNA nanoparticles from amphiphilic block copolymers and describe their hybridization to a complementary single-stranded DNA (ssDNA) oligonucleotide.
DOI: 10.1021/ja503142s
Authors: Carrie R. James, Anthony M. Rush, Thomas Insley, Lela Vuković, Lisa Adamiak, Petr Král, Nathan C. Gianneschi
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: G4195866041, G5726159121
OpenAlex ID: W4234415349