Mutations targeted to a predicted helix in the extreme carboxyl-terminal region of the human estrogen receptor-α alter its response to estradiol and 4-hydroxytamoxifen.
Year: 2002
Type: article
Abstract: Page 13208, Table IV: The units for affinity are given as micromolar but should be nanomolar. The corrected table is shown below:Table IVThe binding of [3H]estradiol to the wild type, S554stop (ΔF), and Q565P mutant hERαReceptorAffinity,K dHill coefficient,nH nmwt hERα0.64 ± 0.411.58 ± 0.18S554stop (ΔF)0.05 ± 0.0071.65 ± 0.36Q565P0.23 ± 0.010.94 ± 0.1The affinity (K d ) and cooperativity (Hill coefficient, nH ) of estradiol binding were measured using baculovirus-expressed ΔF, Q565P, and wt ERα receptors as described under “Experimental Procedures.” Open table in a new tab The affinity (K d ) and cooperativity (Hill coefficient, nH ) of estradiol binding were measured using baculovirus-expressed ΔF, Q565P, and wt ERα receptors as described under “Experimental Procedures.”
Source: Journal of Biological Chemistry
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W4234438564