Mngo-01a Prognostic Cytogenetic Scoring System to Guide the Adjuvant Management of Patients With Atypical Meningioma
Year: 2015
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The appropriate use of adjuvant therapy in patients with gross totally resected atypical meningioma requires an accurate assessment of recurrence risk. We sought to determine whether cytogenetic/genetic characterization may facilitate better estimation of the probability of recurrence. METHODS: We first analyzed our clinical database including high resolution DNA copy number data to identify 11 common copy number aberrations in a pilot cohort of meningiomas of all grades. We summed these aberrations to devise a cytogenetic abnormality score (CAS) and determined the CAS from archived tissue of a separate cohort of 32 patients with gross totally resected atypical meningioma managed with surgery alone. Propensity score adjusted Cox regression was used to determine whether the CAS was predictive of recurrence. RESULTS: An association between higher CAS and higher grade was noted in our pilot cohort with heterogeneity among atypical tumors. Among the 32 patients who underwent gross total resection of an atypical meningioma, the CAS was not significantly associated with age, gender, performance status, or tumor size/location but was associated with the risk of recurrence on univariable analysis (HR per aberration, 1.52, 95% CI 1.08-2.14, p = 0.02). After adjustment, the impact of the dichotomized number of copy aberrations remained significantly associated with recurrence risk (HR 4.47, 95% CI 1.01-19.87, p = 0.05).
Source: Neuro-Oncology
Institutions: Brigham and Women's Hospital, Center for Neuro-Oncology
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4235821871