Faculty Opinions recommendation of A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.
Year: 2019
Type: peer-review
Abstract: A stable latent reservoir for HIV-1 in resting CD4 + T-cells precludes cure [1][2][3] .Curative strategies targeting the reservoir are being tested 4,5 and require accurate, scalable reservoir assays.The reservoir was defined with quantitative viral outgrowth assays (QVOAs) for cells releasing infectious virus following one round of T-cell activation 1 .However, QVOAs and newer assays for
Author: Bruce Walker
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G1012248884, BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy, A Novel Test to Measure Latent Virus in HIV-1 Infected Patients, G358483467, G4573400019, Combined Immunologic Approaches to Cure HIV-1, SBIR Phase II: Development and Optimization of a New Molecular Test to quantify Latent HIV-1 in Samples from HIV-1 Infected Individuals., G59854867, G632742325, SBIR Phase I: Development and optimization of a new molecular test to quantify latent HIV-1 in samples from HIV-1 infected individuals., G7241966796, G8830802036
OpenAlex ID: W4235977505