Faculty Opinions recommendation of Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.
Year: 2017
Type: peer-review
Abstract: A central paradigm within virology is that each viral particle largely behaves as an independent infectious unit.Here we demonstrate that clusters of enteroviral particles are packaged within phosphatidylserine (PS) lipid-enriched vesicles that are non-lytically released from cells and provide greater infection efficiency than free single viral particles.We show that vesicular PS lipids are co-factors to the relevant enterovirus receptors in mediating subsequent infectivity and transmission, in particular to primary human macrophages.We demonstrate that clustered packaging of viral particles within vesicles enables multiple viral RNA genomes to be collectively transferred into single cells.This study reveals a novel mode of viral transmission, where enteroviral genomes are transmitted from cell-to-cell en bloc in membrane-bound PS vesicles instead of single independent genomes.This has implications for facilitating genetic cooperativity among viral quasispecies as well as enhancing viral replication.
Author: Johan Neyts
Institution: Rega Institute for Medical Research
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institutes of Health
OpenAlex ID: W4236012197