Genes of theDrosophilamaternal dorsal group control the specific expression of the zygotic genetwistin presumptive mesodermal cells
Year: 1987
Type: preprint
Abstract: 6ene5 0f the Dr050ph11a materna1 d0r5a1 9r0up c0ntr01 the 5pec1f1c expre5510n 0f the 2y90t1c 9ene tw15t 1n pre5umpuv me50derma1 ce115 8ernard 7h155e, C0r1nne 5t0et2e1, Mar1am E1 Me55a1, and Fa61enne Perr1n-5chm1tt La60rat01re de 66n6t14ue M016cu1a1re de5 Eucary0te5 du CNR5, Un1t6 184 de 8101091e M016cu1a1re et de 66n1e 66n6t14ue de 1•1N5ERM, Facu1t6 de M6dec1ne, 67085 5tra560ur9 C6dex, France At 1ea5t 10 materna11y act1ve 9ene5, the d0r5a1-9r0up 9ene5, and tw0 2y90t1ca11y act1ve 9ene5, tw15t and 5na11, enc0de 1nf0rmat10n f0r the e5ta6115hment 0f the d0r50-ventra1 ax15 1n Dr050ph11a em6ry05.Mutat10n 1n any 0ne 0f the5e 9ene5 re5u1t5 1n part1a1 0r t0ta1 d0r5a112at10n 0f the em6ry0.7w15t mutant5 5h0w part1a1 d0r5a112at10n and a fa11ure 0f me50derm d1fferent1at10n.U51n9 1n 51tu hy6r1d12at10n, we 5h0w that m05t tw15t tran5cr1pt5 are detected 1n the ce115 f0rm1n9 the ventra1 furr0w at 9a5tru1at10n and, 1ater, 1n the ce115 f0rm1n9 the em6ry0n1c me50derm.A 5pec1f1c 1nteract10n 6etween d0r5a1 and tw15t ha5 a1ready 6een de5cr16ed, and we 5h0w that the expre5510n 0f tw15t 15 n0t 0n1y a60115hed 1n em6ry05 de5cended fr0m h0m02y90u5 d0r5a1 fema1e5 6ut a150 1n em6ry05 deve10p1n9 fr0m e995 1a1d 6y fema1e5 h0m02y90u5 f0r the materna1 d0r5a1121n9 mutat10n5, pe11e, ea5ter, and 701L
Source: Genes & Development
DOI: 10.1101/gad.1.7.709
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4236940297