Chemoinformatic-guided engineering of polyketide synthases
Year: 2020
Type: other
Abstract: Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A central challenge in PKS design is replacing a partially reductive module with a fully reductive module through a reductive loop exchange, thereby generating a saturated β-carbon. In this work, we sought to establish an engineering strategy for
Authors: Miranda Werts, Mitchell Thompson, Jessica Wang, Constance Bailey, Yuzhong Liu, Veronica Benites, Edward Baidoo, Leonard Katz, Samantha Chang, Jesus Barajas, Ankita Kothari, Rasha Anayah, Chris Petzold, Jay Keasling, Ravi Lal, Luis Valencia, Andrew Wong, Yan Chen, carolina barcelos, Pablo Crux-Morales, Hector Garcia Martin, Aindrila Mukhopadhyay, Amanda Hernandez, Amin Zargar, Tyler Backman, Arthur Loubat
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4237027811