Arene Dearomatization via a Catalytic N-Centered Radical Cascade Reaction
Year: 2019
Type: preprint
Abstract: This photocatalysis methodology leverages N-centered radicals, from easily prepared γ,δ-unsaturated N-arylsulfonyl enamides, to initiate a carboamination/dearomatization cascade reaction that generates stereodefined 1,4-cyclohexadiene-fused sultams. This unique reactivity serves as a general platform for arene dearomatization and the fused heterocyclic products are viewed as valuable building blocks for drug discovery programs.
Source: ChemRxiv
Authors: Rory McAtee, Efrey Noten, Corey Stephenson
Institution: University of Michigan
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W4237630297