Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
Year: 2021
Type: article
Abstract: (Cell Reports 34, 108703-1–15.e1–e5; February 2, 2021) In the originally published version of this article, author name Leonardo Almeida-Souza was misspelled in the author list. The corrected author name now appears here and with the paper online. The authors regret this error. Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretionHu et al.Cell ReportsFebruary 02, 2021In BriefIn this article, Hu et al. show the importance, for gene regulation, of a genomic region harboring GWAS variants that affect type 2 diabetes risk at the STARD10 locus. They also identify FCHSD2 as a likely mediator of the effects of these variants on insulin secretion. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,200
Funder: Medical Research Council
Awards: Genetic and nutritional control of pancreatic beta cell identity., Roles of GWA genes in controlling pancreatic beta cell function and mass., All-optical deconstruction of the islet wiring patterns underlying insulin secretion in health and disease, Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes, Roles of the type 2 diabetes (T2D)-associated gene C2cd4a in regulating glucose homeostasis in the mouse
OpenAlex ID: W4237715440