Protocol for a systematic review on microRNA profiles and functions in mosquitoes v1
Year: 2018
Type: preprint
Study design: Systematic Review
Abstract: Mosquitoes are incriminated as vectors for many fatal diseases, including malaria, West Nile fever, Dengue Fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) in the mosquitoes interact with multiple target genes to elicit biological functions that have not been determined to date. We conducted a systematic review following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand metabolism, development, and the response to microorganisms. Depending on the study, we found that miRNAs were dysregulated in a species-, sex-, stage-, and tissue/organ-specific manner. Aberrant miRNA expressions were observed on development, metabolism, host-pathogen interactions, and insecticide resistance. Of note, most miRNAs were down-regulated upon pathogen infection. The experimental studies have expanded the miRNA target from 3′ untranslated regions (UTRs) of mosquitoes to 5′UTRs of virus. In addition, we discuss current trends in mosquito miRNA research and offer suggestions for future studies.
Authors: Xinyu Feng, Shuisen Zhou, Jingwen Wang, Wei Hu
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4238072478