Work

Quantification of Photoreceptor Layer Thickness in Normal Eyes Using Optical Coherence Tomography

Year: 2006

Type: article

Abstract: In Brief Objective: To demonstrate the ability to segment and analyze individual intraretinal layers, including the outer retinal complex (ORC; outer nuclear layer and inner and outer segments of the photoreceptor cells), in healthy eyes using images acquired from the latest commercially available optical coherence tomography (OCT) system (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA) and from the ultrahigh resolution OCT (UHR-OCT) prototype. Methods: Thirty-seven eyes from 37 healthy subjects underwent complete ophthalmologic examination using StratusOCT and UHR-OCT. ORC was identified and measured using a segmentation algorithm. Results: For StratusOCT, mean weighted ORC thickness ± SD was 91.1 ± 7.9 μm, and mean weighted total retinal thickness ± SD was determined to be 258.9 ± 10.1 μm. For UHR-OCT, mean weighted ORC thickness ± SD was 96.4 ± 6.3 μm, and mean weighted total retinal thickness ± SD was determined to be 263.4 ± 9.2 μm. There was a higher rate of algorithm failure with UHR-OCT images. Conclusions: Photoreceptor layer thickness can be calculated by measuring ORC on OCT images using a macular segmentation algorithm. ORC values may serve as a useful objective parameter in determining the efficacy of various therapeutic modalities that target the photoreceptor layer in various diseases. Optical coherence tomography was used to segment and quantify individual intraretinal layers, such as the outer retinal complex (ORC; outer nuclear layer and inner and outer segments of the photoreceptor cells) in 37 healthy eyes. The ORC measurement may be a useful objective parameter in determining the efficacy of various therapies targeting the photoreceptor layer.

Source: Retina

DOI: 10.1097/00006982-200607000-00011

Authors: ANNIE CHAN, JAY S. DUKER, HIROSHI ISHIKAWA, TONY H. KO, JOEL S. SCHUMAN, JAMES G. FUJIMOTO