Faculty Opinions recommendation of Malassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.
Year: 2019
Type: peer-review
Abstract: Inflammatory bowel disease (IBD) is characterized by alterations in the intestinal microbiota and altered immune responses to gut microbiota.Evidence is accumulating that IBD is influenced by not only commensal bacteria but also commensal fungi.We characterized fungi directly associated with the intestinal mucosa in healthy people and Crohn's disease patients and identified fungi specifically abundant in patients.One of these, the common skin resident fungus Malassezia restricta, is also linked to the presence of an IBD-associated polymorphism in the gene for CARD9, a signaling adaptor important for anti-fungal defense.M. restricta elicits innate
Author: Alexander Idnurm
Institution: The University of Melbourne
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, Inflammatory Bowel and Immunobiology Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Clinical and Translational Science Institute, University of California, Los Angeles
OpenAlex ID: W4238290638