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Year: 2013

Type: article

Abstract: A lovely study in this month’s issue of the Journal provides a nice example of using complementary approaches to dissect cell-specific function in an animal model of liver injury. The study by Morán-Salvador et al. examines the contributions of PPARγ activity in both parenchymal and non-parenchymal cells during CCl4-induced liver injury by combining a method to genetically deplete this gene in specific cell types in vivo with a model of tissue function using precision cut liver slices (PCLS) ex vivo.

Source: Journal of Hepatology

DOI: 10.1016/j.jhep.2013.08.004

Author: Scott L. Friedman

Institution: Icahn School of Medicine at Mount Sinai

Language: English

Topic: Liver physiology and pathology

Subfield: Hepatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,500