Correction: Expression of death receptor 4 is positively regulated by MEK/ERK/AP-1 signaling and suppressed upon MEK inhibition.
Year: 2020
Type: erratum
Abstract: Expression of Death Receptor 4 Is Positively Regulated by MEK/ERK/AP-1 Signaling and Suppressed upon MEK InhibitionJournal of Biological ChemistryVol. 291Issue 41PreviewDeath receptor 4 (DR4) is a cell surface receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and triggers apoptosis upon ligation with TRAIL or aggregation. MEK/ERK signaling is a well known and the best-studied effector pathway downstream of Ras and Raf. This study focuses on determining the impact of pharmacological MEK inhibition on DR4 expression and elucidating the underlying mechanism. We found that several MEK inhibitors including MEK162, AZD6244, and PD0325901 effectively decreased DR4 protein levels including cell surface DR4 in different cancer cell lines. Full-Text PDF Open Access VOLUME 291 (2016) PAGES 21694–21702 In Fig. 1C, the tubulin immunoblot for HCT116 cells was reused for H460 cells because the original data were mislabeled. This error has now been corrected and does not affect the results or conclusions of this work.
Source: Journal of Biological Chemistry
Language: English
Topic: Melanoma and MAPK Pathways
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W4238795284