Work

Anti-inflammatory protein TNFα-stimulated gene-6 (TSG-6) reduces inflammatory response after brain injury in mice

Year: 2021

Type: article

Abstract: Background Current research suggests that the glial scar surrounding penetrating brain injuries is instrumental in preserving the surrounding uninjured tissue by limiting the inflammatory response to the injury site. We recently showed that tumor necrosis factor (TNF)-stimulated gene-6 (TSG-6), a well-established anti-inflammatory molecule, is present within the glial scar. In the present study we investigated the role of TSG-6 within the glial scar using TSG-6 null and littermate control mice subjected to penetrating brain injuries. Results Our findings show that mice lacking TSG-6 present a more severe inflammatory response after injury, which was correlated with an enlarged area of astrogliosis beyond the injury site. Conclusion Our data provides evidence that TSG-6 has an anti-inflammatory role within the glial scar.

Source: BMC Immunology

DOI: 10.1186/s12865-021-00443-7

Authors: Kazadi Nadine Mutoji, Mingxia Sun, Amanda Nash, Sudan Puri, Vincent Hascall, Vivien J. Coulson-Thomas

Institutions: University of Houston, Rice University, Cleveland Clinic

Language: English

Topic: Traumatic Brain Injury and Neurovascular Disturbances

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590