Faculty Opinions recommendation of A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
Year: 2013
Type: peer-review
Abstract: Allergic disease is very common and carries substantial public health burdens.We conducted a meta-analysis of genome-wide association with self-reported cat, dust-mite, and pollen allergy in 53,862 individuals.We used generalized estimating equations to model shared and allergy-specific genetic effects.We identified 16 shared susceptibility loci with P<5×10 -8 , including 8 loci previously associated with asthma, as well as 4p14 near TLR1, TLR6, and TLR10 (rs2101521: P=5.3× -21 ); 6p21.33 near HLA-C and MICA (rs9266772: P=3.2×10 -12 ); 5p13.1 near PTGER4 (rs7720838: P=8.2×10 -11 ); 2q33.1 in PLCL1 (rs10497813: P=6.1×10 -10 ); 3q28 in LPP (rs9860547: P=1.2×10 -9 ); 20q13.2 in NFATC2 (rs6021270: P=6.9×10 -9 ); 4q27 in ADAD1 (rs17388568: P=3.9×10 -8 ); and 14q21.1 near FOXA1 and TTC6 (rs1998359: P=4.8×10 -8 ).We identified one locus with substantial evidence for differences in effects across allergies, at 6p21.32 in the class II HLA region (rs17533090: P=1.7×10 -12 ), strongly associated with cat allergy.Our study sheds new light on the shared etiology of immune and autoimmune disease.
Author: Marc Rothenberg
Institution: Cincinnati Children's Hospital Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4239047337