Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity.
Year: 1996
Type: article
Abstract: Vol. 270, p. 12614 We inadvertently failed to cite the work of Carroll et al.(1.Carroll J.M. Albers K.M. Garlick J.A. Harrington R. Taichman L.B. Proc. Natl. Acad. Sci. U. S. A. 1993; 90: 10270-10274Crossref PubMed Scopus (132) Google Scholar) which shows that the human involucrin promoter upstream regulatory region, fused to SV40 sequences, can drive tissue-specific transcription of a β-galactosidase gene in transgenic mice. Our work (2.Crish J.F. Howard J.M. Zaim T.M. Murthy S. Eckert R.L. Differentiation. 1993; 53: 191-200Crossref PubMed Scopus (76) Google Scholar) shows that a 6-kilobase segment of the gene, including the structural protein, targets expression to epidermis. These results are fully consistent with the important regulatory elements being localized upstream of the transcription start site.
Source: Journal of Biological Chemistry
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,430
OpenAlex ID: W4239069604