Pi-03 a Randomized Study of Intra-operative Autologous Retropubic Urethral Sling on Urinary Control After Robot Assisted Radical Prostatectomy
Year: 2016
Type: conference-abstract
Abstract: follow-up among survivors was 3.86 years.P-MIBC patients had significantly worse OS (p ¼ 0.026), RFS (p ¼ 0.002), and CSS (p ¼ 0.022) on univariable analysis as compared to DN-MIBC patients (Fig. 1).After adjusting for pathologic T stage on multivariable analysis, P-MIBC associations with OS and CSS were no longer significant; however, P-MIBC remained associated with a significantly increased risk of recurrence compared to DN-MIBC (HR: 2.40, 95% CI¼ 1.38-4.19,p ¼ 0.002).CONCLUSIONS: Patients with P-MIBC appear less likely to respond to NAC than DN-MIBC, though these findings should be confirmed in prospective studies.The mechanisms for platinum resistance in P-MIBC are under investigation, but the benefits of earlier surgical intervention before progression to MIBC cannot be overstated.
Source: The Journal of Urology
Authors: Hao Nguyen, Michael Leapman, Sanoj Punnen, Janet Cowan, Clint Cary, Christopher Welty, Matthew Cooperberg, Maxwell Meng, Kirsten Greene, Sima Porten, Maurice Garcia, Peter Carroll
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4239092758