Work

Exosomes: Mechanisms of Uptake

Year: 2015

Type: article

Abstract: Exosomes are 30–100 nm microvesicles which contain complex cellular signals of RNA, protein and lipids. Because of this, exosomes are implicated as having limitless therapeutic potential for the treatment of cancer, pregnancy complications, infections, and autoimmune diseases. To date we know a considerable amount about exosome biogenesis and secretion, but there is a paucity of data regarding the uptake of exosomes by immune and non-immune cell types (e.g., cancer cells) and the internal signalling pathways by which these exosomes elicit a cellular response. Answering these questions is of paramount importance.

Source: Journal of Circulating Biomarkers

DOI: 10.33393/jcb.2015.2057

Authors: Kelly J. McKelvey, Katie L. Powell, Anthony W. Ashton, Jonathan M. Morris, Sharon A. McCracken

Institutions: The University of Sydney, Royal North Shore Hospital, NSW Health Pathology

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,617