Work

1115: The Effect of Treatment Strategy on Stone Comminution Efficiency in Shock Wave Lithotripsy

Year: 2004

Type: conference-abstract

Abstract: UROLOGY® metastatic nodules (p=O.l404 and P=0.0335, respectively).In survival experiments, in situ Dc/IL-12 injection demonstrated a small but statistically significant advantage (p=0.0041).Subcutaneous, tumor lysate pulsed DC/IL-12 also significantly decreased tumor size (p=O.Ol52) but the decrease in the number of spontaneous lung metastases and the increase in survival did not achieve statistical significance.Both in situ and subcutaneous treatment enhanced cytolytic activities of Natural Killer (NK) cells and Cytotoxic T Lymphocytes (CTL).CONCLUSIONS: In this pre-clinical model, gene-modified DC based intratumoral immunotherapy was shown to be an effective therapeutic strategy for locally advanced prostate cancer based on tumor growth suppression, inhibition of metastasis and survival improvement.

Source: The Journal of Urology

DOI: 10.1016/s0022-5347(18)38352-6

Authors: Yufeng Zhou, Charles G. Marguet, Michaella E. Maloney, Franklin H. Cocks, Glenn M. Preminger, Pei Zhong

Language: English

Topic: Kidney Stones and Urolithiasis Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Defense, National Cancer Institute, DOD Prostate Cancer Research Program

OpenAlex ID: W4239828891

Cites:

Cited by: 5

Related to: 10