New generation antidepressants for depression in children and adolescents: a network meta-analysis
Year: 2020
Type: article
Study design: Study Protocol
Abstract: ObjectivesThis is a protocol for a Cochrane Review (intervention).The objectives are as follows:To investigate, via network meta-analyses (NMA), the comparative effectiveness and safety of different newer generation antidepressants in children and adolescents with a diagnosed major depressive disorder (MDD).Specific objectives, in order of priority, are to:1. estimate the relative effects of newer generation antidepressants compared with placebo and with each other on depression, functioning, suicide-related outcomes and other adverse outcomes; 2. estimate the relative ranking of the included newer generation antidepressants for the outcomes of depression, functioning, suiciderelated outcomes and other adverse outcomes; and, 3. examine whether the relative effects on clinician-rated depression symptoms and suicide-related outcomes estimated in objectives 1 and 2 are modified by age, treatment duration, baseline severity and pharmaceutical industry funding of the antidepressant under evaluation. New generation antidepressants for
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4239841001