Work

Characterization of Toxicokinetics and Toxicodynamics with Linear Systems Theory: Application to Lead-Associated Cognitive Decline

Year: 2001

Type: article

Abstract: We present a theoretical approach to analysis of toxicokinetics and toxicodynamics using linear systems theory. In our approach, we define two impulse response functions that characterize the kinetic behavior of an environmental agent in the body and the dynamic time-course behavior of its effect on the body. This approach provides a formalism for understanding the relation among exposure, dose, and cumulative biologically effective dose and for understanding the implications of an effect time-course on cross-sectional and longitudinal data analyses. We use lead-associated cognitive decline as a specific example where the approach may be applied.

Source: Environmental Health Perspectives

DOI: 10.1289/ehp.01109361

Authors: J M Links, B S Schwartz, D Simon, K Bandeen-Roche, W F Stewart

Institution: Johns Hopkins University

Language: English

Topic: Heavy Metal Exposure and Toxicity

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,500