Year: 2019
Type: review
Abstract: Here we present a guide on ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties on mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N, (ii) ion mobility does not measure surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model, (iii) methods relying on calibration are empirical (and thus may provide method-dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort towards establishing primary standards and reference materials for ion mobility, and provides recommendations to do so.
Source: Mass Spectrometry Reviews
DOI: 10.1002/mas.21585
Authors: Valérie Gabelica, Alexandre A. Shvartsburg, Carlos Afonso, Perdita Barran, Justin L.P. Benesch, Christian Bleiholder, Michael T. Bowers, Aivett Bilbao, Matthew F. Bush, J. Larry Campbell, Iain D.G. Campuzano, Tim Causon, Brian H. Clowers, Colin S. Creaser, Edwin De Pauw, Johann Far, Francisco Fernandez‐Lima, John C. Fjeldsted, Kevin Giles, Michael Groessl, Christopher J. Hogan, Stephan Hann, Hugh I. Kim, Ruwan T. Kurulugama, Jody C. May, John A. McLean, Kevin Pagel, Keith Richardson, Mark E. Ridgeway, Frédéric Rosu, Frank Sobott, Konstantinos Thalassinos, Stephen J. Valentine, Thomas Wyttenbach
Institutions: Centre National de la Recherche Scientifique, Université de Bordeaux, Inserm, Institut Européen de Chimie et Biologie, Acides nucléiques: Régulations naturelles et artificielles, Wichita State University, Université de Rouen Normandie, University of Manchester, University of Oxford, Florida State University, University of California, Santa Barbara, Pacific Northwest National Laboratory, University of Washington, Sciex (Canada), Amgen (United States), BOKU University, Washington State University, Loughborough University, University of Liège, Florida International University, Agilent Technologies (United States), Waters (United Kingdom), University of Bern, University Hospital of Bern, Tofwerk (Switzerland), University of Minnesota, Korea University, Vanderbilt University, Freie Universität Berlin, Bruker (United States), University of Leeds, University of Antwerp, University of London, Institute of Structural and Molecular Biology, University College London, Birkbeck, University of London, West Virginia University
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W2913182573