AmrZ is a positive regulator of swimming motility in Pseudomonas stutzeri
Year: 2016
Type: preprint
Abstract: amrZ , a master regulator protein conserved across Pseudomonads, can be either a positive or negative regulator of swimming motility depending on the species examined. To better understand plasticity in the regulatory function of AmrZ, we characterized the mode of regulation for this protein for swimming motility in P. stutzer i. As in P. syringae , AmrZ functions as a positive regulator of motility within P. stutzeri , which suggests that the functions of this protein with regards to swimming motility have switched at least twice across Pseudomonads. We further show that divergence between P. stutzeri and P. aeruginosa alleles of AmrZ does not explain shifts in regulatory mode. Further investigation into the mechanisms underlying shifts in regulatory function for AmrZ could provide unique insights into the evolution of bacterial regulatory proteins.
Institution: University of Arizona
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4241398724