Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians
Year: 2013
Type: erratum
Abstract: To discover susceptibility genes of late-onset Alzheimer's disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese Genetic Consortium for Alzheimer Disease (JGSCAD), Koreans, and Caucasians from the Alzheimer Disease Genetic Consortium (ADGC).In Stage 1, we evaluated data for 5,877,918 genotyped and imputed SNPs in Japanese cases (n = 1,008) and controls (n = 1,016).Genome-wide significance was observed with 12 SNPs in the APOE region.Seven SNPs from other distinct regions with p-values ,2610 25 were genotyped in a second Japanese sample (885 cases, 985 controls), and evidence of association was confirmed for one SORL1 SNP (rs3781834, P = 7.33610 27 in the combined sample).Subsequent analysis combining results for several SORL1 SNPs in the Japanese, Korean (339 cases, 1,129 controls) and Caucasians (11,840 AD cases, 10,931 controls) revealed genome wide significance with rs11218343 (P = 1.77610 29 ) and rs3781834 (P = 1.04610 28 ).SNPs in previously established AD loci in Caucasians showed strong evidence of association in Japanese including rs3851179 near PICALM (P = 1.71610 25 ) and rs744373 near BIN1 (P = 1.39610 24 ).The associated allele for each of these SNPs was the same as in Caucasians.These data demonstrate for the first time genome-wide significance of LOAD with SORL1 and confirm the role of other known loci for LOAD in Japanese.Our study highlights the importance of examining associations in multiple ethnic populations.
Source: PLoS ONE
Authors: Akinori Miyashita, Asako Koike, Gyungah Jun, Li-San Wang, Satoshi Takahashi, Etsuro Matsubara, Takeshi Kawarabayashi, Mikio Shoji, Naoki Tomita, Hiroyuki Arai, Takashi Asada, Yasuo Harigaya, Masaki Ikeda, Masakuni Amari, Haruo Hanyu, Susumu Higuchi, Takeshi Ikeuchi, Masatoyo Nishizawa, Masaichi Suga, Yasuhiro Kawase, Hiroyasu Akatsu, Kenji Kosaka, Takayuki Yamamoto, Masaki Imagawa, Tsuyoshi Hamaguchi, Masahito Yamada, Takashi Morihara, Masatoshi Takeda, Takeo Takao, Kenji Nakata, Yoshikatsu Fujisawa, Ken Sasaki, Ken Watanabe, Kenji Nakashima, Katsuya Urakami, Terumi Ooya, Mitsuo Takahashi, Takefumi Yuzuriha, Kayoko Serikawa, Seishi Yoshimoto, Ryuji Nakagawa, Jong-Won Kim, Chang-Seok Ki, Hong-Hee Won, Duk L. Na, Sang Won Seo, Inhee Mook-Jung, Peter St. George-Hyslop, Richard Mayeux, Jonathan L. Haines, Margaret A. Pericak-Vance, Makiko Yoshida, Nao Nishida, Katsushi Tokunaga, Ken Yamamoto, Shoji Tsuji, Ichiro Kanazawa, Yasuo Ihara, Gerard D. Schellenberg, Lindsay A. Farrer, Ryozo Kuwano
Institutions: Johns Hopkins University, Brain Research Institute, Niigata University, Niigata University, University of Michigan, Hitachi (Japan), Boston University, VA Ann Arbor Healthcare System, University of California, Los Angeles, University of Pennsylvania, Iwate Medical University, Hirosaki University, University of North Texas Health Science Center, Tohoku University, University of Tsukuba, University of Pittsburgh, Rush University Medical Center, Maebashi Red Cross Hospital, Gunma University, Tokyo Medical University, Banner Sun Health Research Institute, University of Miami, Kurihama Medical and Addiction Center, Dr. John T. Macdonald Foundation, University of Washington, National Alzheimer's Coordinating Center, Northwestern University, Fukushimura Hospital, Choju Medical Institute, Kanazawa University, Harvard University, Massachusetts General Hospital, The University of Osaka, Mayo Clinic, Saiseikai Takaoka Hospital, Swedish Medical Center, Swedish Medical Center, University of Southern California, Tottori University, Fukuoka University, Hizen Psychiatric Center, Ureshino Medical Center, Samsung Medical Center, Sungkyunkwan University, University of California, San Francisco, Seoul National University, University of Cambridge, Columbia University, Vanderbilt University, The University of Tokyo, Doshisha University, Kyushu University, National Center of Neurology and Psychiatry, Medical Institute of Bioregulation, Kyushu University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
Funders: U.S. Department of Veterans Affairs, Alzheimer's Association, Dana Foundation, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, AstraZeneca, GlaxoSmithKline, Novartis, Office of Research and Development, F. Hoffmann-La Roche, Medpace, Synarc, Alzheimer's Disease Neuroimaging Initiative, Northern California Institute for Research and Education, Wellcome Trust, Alzheimer's Research Trust, Newcastle University, Ministry of Education, Culture, Sports, Science and Technology, Stichting MS Research, Elan, Eisai, North Bristol NHS Trust, Universitat de Barcelona, Hersenstichting, National Institutes of Health, Genentech, Medical Research Council, Japan Society for the Promotion of Science, National Institute on Aging, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering
Awards: G100845555, G104586243, G1173778324, G1309605592, G1591652791, G171348792, G2022000225, G2038718543, G2152643862, G2409989180, G2649392419, G2835601961, G2877684854, G2929235049, G29951154, G3131374986, G3146424788, G3173811024, G3186481112, National Alzheimer's Coordinating Center, G3392333875, THE HUMAN BRAINOME:genome, transcriptome and proteome interaction in human cortex, G346328595, G3553156159, G3710456697, G3870774570, G3946457848, G3966393351, "MR Morphometrics and Cognitive Decline Rate in Large-Scale Aging Studies", G43180419, Assessment of Driving Safety in Aging, Mild Cognitive Impairment and Dementia, G5207404921, G5209990037, Alzheimer's Disease Genetics Consortium, G5366509656, G5389965057, G5678256514, G598830915, G6259281481, G6412110892, G6425121803, G6648385527, G6836910998, G6899163935, G6948409098, Arizona Alzheimer's Disease Core Center, G7315666996, Genetic Consortium for Late Onset Alzheimer's Disease, Amyloid Imaging, VMCI, and Analysis for ADNI, G7799614282, G781725486, G793122433, G8150283386, G8275783879, Genome Wide associate analysis of Alzheimer's Disease, G8506111834, G8636843673, G9000030076, G9000039018, G9000122267, G9000122335, G9000132673, G9000159195, G9000196338, G920654007
OpenAlex ID: W4241725622