Year: 2021
Type: article
Abstract: High-valent organoiodine reagents have many reaction characteristics similar to transition metals, and high-valent organoiodine-mediated reactions feature mild reaction conditions, good product selectivity, high yield and environmental friendliness.Therefore, they have been widely studied and applied in organic synthesis.The recent research progress of 2-iodoxybenzoic acid in organic synthesis is reviewed, including the oxidation of hydroxyl group, nitrogen-containing compounds and sulfur-containing compounds, the preparation of α,β-unsaturated carbonyl compounds and esters, and the application in asymmetric synthesis.The recent improvement of IBX is also introduced.Keywords 2-iodoxybenzoic acid (IBX); oxidation; organic synthesis; high-valent organoiodine 高价有机碘化学是有机化学学科的一个分支. 第一 个高价有机碘试剂是由 Willgerodt [1] 于 1886 年合成的, 在之后的 120 余年里, 高价有机碘化学的发展较为缓慢, 直到 Dess-Martin [2] 试剂[(1,1,1-三乙酰氧基)-1,1-二氢-1,2-苯碘酰-3(1H)-酮, DMP]出现后, 因其优异的反应性 能, 使高价有机碘试剂在有机化学研究领域中获得了广 泛关注.高价有机碘试剂中的碘有三价和五价两种价态. 在 其分子中, 碘的 5p 轨道与配体的原子/分子轨道相互重 叠, 可形成新的三中心四电子或两中心四电子化学键.
Authors: Shuyu Zhang, Haotian Wu, E Tang
Institution: Yunnan University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4241807653