Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway
Year: 2017
Type: article
Abstract: (Cell Reports 16, 950–966; July 26, 2016) In the originally published version of this article, Figure 1 had an erroneous panel A (0 hr, 24 hr, Olig2-ko mGSCs) that was a duplicate of panel E (0 hr, 24 hr, TPM-mNSCs). The corrected figure now appears below. The authors regret this error.Figure 1Phosphorylation Status of Olig2 Affects Invasion/Migration of mNSCs and mGSCs (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β PathwaySingh et al.Cell ReportsJuly 7, 2016In BriefSingh et al. show that the phosphorylation status of a CNS-specific transcription factor, OLIG2, dictates the switch from the proliferative to invasive phenotype in glioblastoma. Unphosphorylated OLIG2 induces invasion through upregulation of the TGF-β2 pathway. The authors provide a putative mechanism through which OLIG2 regulates both proliferation and invasion in GBM cells. Full-Text PDF Open Access
Source: Cell Reports
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,620
OpenAlex ID: W4243147962