Stem cell epigenetics in medical therapy
Year: 2021
Type: book-chapter
Abstract: The goal of regenerative medicine is to replace lost or damaged cell tissues through stem cell therapy. This can potentially be accomplished using pluripotent or adult stem cells directly from humans or from engineered somatic cells via reprogramming or transdifferentiation. A profound knowledge of the molecular mechanisms, such as DNA methylation and histone modifications, underlying embryonic and somatic stem cell function and a detailed characterization of the driving forces related to these cells, such as induced pluripotent stem cells (iPSCs) reprogramming, may enable us to design better strategies. These strategies must aim for the generation of stem cells without tumorigenicity or immunogenicity to be suitable for clinical application. Here, we review our current understanding of the role of epigenetics in stem cells related to medical therapy, which will pave the way toward exploitation of therapeutic approaches to prevent or cure diseases.
Source: Medical Epigenetics
Authors: Baoli Cheng, Liqi Shu, Emily G Allen, Peng Jin
Institution: Emory University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4243928712