Work

Mutated PI 3-Kinases: Cancer Targets on a Silver Platter

Year: 2005

Type: article

Abstract: The PI3K signaling pathway is upregulated in numerous cancers.The catalytic subunit p110α of PI3K shows hot spot mutations in nearly 30% of several types of solid tumors.The most prominent of these mutations result in gain of enzymatic function, activate Akt signaling and induce oncogenic cellular transformation.The mutated p110α proteins are ideal targets for specific small molecule inhibitors that discriminate between the oncogenic and the wild-type forms of the enzyme.Such inhibitors could become highly effective anti-cancer drugs.

Source: Cell Cycle

DOI: 10.4161/cc.4.4.1593

Authors: Sohye Kang, Andreas G. Bader, Li Zhao, Peter K. Vogt

Institution: Scripps Research Institute

Language: English

Topic: PI3K/AKT/mTOR signaling in cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute