Work

DNA vaccines and apoptosis: to kill or not to kill?

Year: 2003

Type: article

Abstract: The apoptotic machinery has become the latest target of vaccinologists attempting to improve the efficacy of DNA vaccines.While workers have previously sought to induce apoptotic death in transfected DCs as a means to activate immunity, a new approach (see related article on pages 109-117) instead seeks to delay apoptosis in host DCs after DNA vaccination.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci19069

Authors: Wolfgang W. Leitner, Nicholas P. Restifo

Institutions: National Institutes of Health, National Cancer Institute, National Cancer Institute

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Cancer Institute