Year: 1983
Type: paratext
Abstract: The relationships among the HLA system, psychiatric disorders, and psychotropic drugs are reviewed.Research findings of significant associations between a number of antigens of the HLA system and clinical phenotypes of schizophrenia and manic-depressive disorders are noted, and directions for future research are suggested.The hypothesis that HLA determinants interfere with the interaction between neurorransmitters and/or psychotropic drugs and specific receptors is discussed, and clinical implications of HLA/A1 reactions to chlorpromazine and haloperidol, and of the HLA/A1 cross-reacting antigens are analyzed.
Source: Schizophrenia Bulletin
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4244479732