Work

Faculty Opinions recommendation of Fixation and spread of somatic mutations in adult human colonic epithelium.

Year: 2019

Type: peer-review

Abstract: takes years due to slow stem cell turnover d Crypt fission enables lateral expansion of mutant clones d Biases in both fixation and expansion increase age-related pro-oncogenic burden

Source: Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI: 10.3410/f.733246456.793563861

Author: Todd Nystul

Institution: University of California, San Francisco

Language: English

Topic: Genetic factors in colorectal cancer

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Cancer Research UK, National Institute for Health and Care Research, University of East Anglia, Norfolk and Norwich University Hospitals NHS Foundation Trust, Medical Research Council, Biotechnology and Biological Sciences Research Council, NIHR Cambridge Biomedical Research Centre, Cancer Research UK Cambridge Institute, University of Cambridge

Awards: Fundamental and applied biology of intestinal stem cells., G4900274166

OpenAlex ID: W4244532640

Cites: 41

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Related to: 10