Faculty Opinions recommendation of Dietary zinc and the control of Streptococcus pneumoniae infection.
Year: 2019
Type: peer-review
Abstract: Human zinc deficiency increases susceptibility to bacterial infection.Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear.Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency.We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model.Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced.Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised.S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells.Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences. Author summaryZinc deficiency affects one-third of the world's population and is associated with an increased susceptibility to bacterial infection.Despite this, the molecular basis for how zinc deficiency compromises host control of infection remains to be understood.We show that dietary zinc deficiency impacts host tissue zinc abundances and its mobilization during infection by the major respiratory pathogen Streptococcus pneumoniae.Zinc acts as a direct antimicrobial against the pathogen, mobilized by phagocytic cells as a component
Authors: Eric Skaar, Lauren Palmer
Language: English
Topic: Trace Elements in Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
Awards: Molecular insights into bacterial metal ion homeostasis and toxicity, Multiplexed bio-imaging mass spectrometry, Aptamer imaging mass spectrometry for biomarker quantification, Proteins and glycans in host-pathogen interactions: targets for novel drugs and vaccines, Defining the role of zinc at the host-pneumococcal interface, New molecular tools to study the mechanisms of bacterial metal homeostasis, Investigating the antimicrobial activity of zinc at the host-pneumococcal interface, Neue Methoden für ein sensitives, quantitatives und dreidimensionales Multiplexverfahren auf Basis von Kopplungstechniken zur Erforschung des Wirkmechanismus von Zinktransportern im alternden Mausgehirn, The molecular basis for manganese uptake by pathogenic bacteria.
OpenAlex ID: W4245060617