Work

PharmVar GeneFocus: CYP2D6

Year: 2019

Type: review

Abstract: The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism of numerous drugs and, thus, can impact drug efficacy and safety. This GeneFocus provides a comprehensive overview and summary of CYP2D6 genetic variation and describes how the information provided by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC).

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1002/cpt.1643

Authors: Charity Nofziger, Amy J. Turner, Katrin Sangkuhl, Michelle Whirl‐Carrillo, José A.G. Agúndez, John L. Black, Henry M. Dunnenberger, Gualberto Ruano, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Andrea Gaedigk

Institutions: Medical College of Wisconsin, RTDS Technologies (Canada), Children's Hospital of Wisconsin Research Institute, Stanford University, Instituto de Salud Carlos III, Mayo Clinic, Endeavor Health, Hartford Hospital, Genomas (United States), University of Otago, Bellevue Hospital Center, Children's Mercy Hospital, University of Missouri–Kansas City

Language: English

Topic: Pharmacogenetics and Drug Metabolism

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: PHARMacogene VARiation Consortium, PharmGKB: pharmacogenomics knowledge for precision medicine

OpenAlex ID: W4245269458

FWCI: 4.646

Cites: 101

Cited by: 243

Related to: 10