Work

Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation

Year: 2017

Type: article

Abstract: Skin fibroblasts were obtained from a 42-year-old Alzheimer's disease (AD) patient carrying mutations in the PSEN1 gene. An iPSC line was successfully established using the Sendai-virus (SeV) delivery system. The patient-specific iPSCs were free of genomically integrated reprogramming genes, had the specific mutation, expressed the expected pluripotency markers, and had the potential to differentiate into cells of all three germ layers. Our model might offer a robust platform for further study of the pathomechanism of this disease as well as drug testing and gene therapy studies.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2017.12.005

Authors: Yanlin Wang, Na Jing, Linlin Su, Changhe Shi, Pei Zhang, Zhilei Wang, Huifang Sun, Jing Yang, Yutao Liu, Xuejun Wen, Jin Zhang, Shoutao Zhang, Yuming Xu

Institutions: First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Tongji University, Virginia Commonwealth University, Shanghai East Hospital, First Affiliated Hospital Zhejiang University, Zhejiang University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360

Funders: National Natural Science Foundation of China, Zhengzhou University, Education Department of Henan Province, Science and Technology Department of Henan Province, First Affiliated Hospital of Zhengzhou University

Awards: G1734784790, G3280683047, G4403403120, G4847697638, G5056883063, G5459373459, G5462707618, G5569706557, CHIP蛋白参与脊髓小脑共济失调3型发病的分子机制及潜在治疗策略, G6723756946, G7881827450

OpenAlex ID: W4245370057

FWCI: 0.112

Cites: 2

Cited by: 5

Related to: 10