Year: 2021
Type: supplementary-materials
Abstract: Preparation of 6,7,8-trimethyllumazine 6,7,8-Trimethyllumazine was synthesized along a route described previously starting out with the preparation of 6-methylaminouracil (Masuda, 1957).10 6-Methylaminouracil.A mixture of 6-chlorouracil (3 mmol, 0.44 g) and methylamine (40 wt.% in H2O, 5 ml) was stirred under reflux overnight.The white solid (0.37 g, 88%) was harvested by filtration, washed with water (5 ml), methanol (10 ml), and Et2O (20 ml), and dried over P2O5; 1 H NMR (DMSO-6d, 400 MHz): δ [ppm] = 10.11-10.07(m, 2H), 6.03-6.01(m, 1H), 4.35 (s, 1H), 2.64 (d, 3H, J = 1.22 Hz); 13 C NMR (DMSO-6d, 100 MHz): δ [ppm] = 164.1,154.9, 150.8, 72.3, 28.3; 15 HRMS (ESI): m/z for C5H6O2N3 [M-H] -calculated: 140.0485, found: 140.0466.
Institutions: University of Freiburg, Technical University of Munich
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
OpenAlex ID: W4245450543