Year: 2021
Type: review
Abstract: Brain perturbation studies allow detailed causal inferences of behavioral and neural processes. Because the combination of brain perturbation methods and neural measurement techniques is inherently challenging, research in humans has predominantly focused on non-invasive, indirect brain perturbations, or neurological lesion studies. Non-human primates have been indispensable as a neurobiological system that is highly similar to humans while simultaneously being more experimentally tractable, allowing visualization of the functional and structural impact of systematic brain perturbation. This review considers the state of the art in non-human primate brain perturbation with a focus on approaches that can be combined with neuroimaging. We consider both non-reversible (lesions) and reversible or temporary perturbations such as electrical, pharmacological, optical, optogenetic, chemogenetic, pathway-selective, and ultrasound based interference methods. Method-specific considerations from the research and development community are offered to facilitate research in this field and support further innovations. We conclude by identifying novel avenues for further research and innovation and by highlighting the clinical translational potential of the methods.
Source: NeuroImage
Authors: P. Christiaan Klink, Jean-François Aubry, Vincent P. Ferrera, Andrew S. Fox, Sean Froudist-Walsh, Béchir Jarraya, Elisa E. Konofagou, Richard J. Krauzlis, Adam Messinger, Anna S. Mitchell, Michael Ortiz-Rios, Hiroyuki Oya, Angela C. Roberts, Anna Wang Roe, Matthew F.S. Rushworth, Jérôme Sallet, Michael Christoph Schmid, Charles E. Schroeder, Jordy Tasserie, Doris Y. Tsao, Lynn Uhrig, Wim Vanduffel, Melanie Wilke, Igor Kagan, Christopher I. Petkov
Institutions: Netherlands Institute for Neuroscience, Centre National de la Recherche Scientifique, Inserm, Université Paris Sciences et Lettres, Physique pour la médecine Paris, ESPCI Paris, Columbia University Irving Medical Center, Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, University of California, Davis, New York University, Université de Versailles Saint-Quentin-en-Yvelines, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Hôpital Foch, National Eye Institute, National Institute of Mental Health, University of Oxford, German Primate Center, Leibniz ScienceCampus Primate Cognition, Newcastle University, University of Iowa, University of Cambridge, Zhejiang University, Lyon 1 Université, Wellcome Centre for Integrative Neuroimaging, Institut Cellule Souche et Cerveau, University of Fribourg, Nathan Kline Institute for Psychiatric Research, California Institute of Technology, Howard Hughes Medical Institute, Harvard University, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, KU Leuven, Universitätsmedizin Göttingen, University of Göttingen
Language: English
Topic: Primate Behavior and Ecology
Subfield: Social Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $3,300
Funders: National Science Foundation, Howard Hughes Medical Institute, Eli Lilly and Company, Wellcome Trust, Hermann und Lilly Schilling-Stiftung für Medizinische Forschung, European Commission, Deutsche Forschungsgemeinschaft, Agence Nationale de la Recherche, National Natural Science Foundation of China, Fonds Wetenschappelijk Onderzoek, KU Leuven, Fondation Bettencourt Schueller, Vlaamse regering, National Institutes of Health, Horizon 2020 Framework Programme, Medical Research Council, European Research Council, National Key Research and Development Program of China, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Eye Institute, National Institute on Deafness and Other Communication Disorders, California National Primate Research Center, H2020 European Research Council, CHIST-ERA, Natural Science Foundation of Zhejiang Province
Awards: Thérapie et Neurostimulation cérébrale de très haute précision par Ultrasons Transcraniens, G1379347371, Focused ultrasound for noninvasive brain stimulation, G1644354792, Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception, G1862068825, G190515515, Functional interactions across attention regions: a combined optogenetic, fMRI and electrophysiology study., G21273325, G2486599622, G2605431732, G3320741918, G3714523229, G3820619147, G3879436857, G3936970252, G3973648083, G4199552044, G434337789, G4369679783, G4829066736, G5183059594, Characterising neural networks of thalamo-cortical interactions important for cognition in primates., G5663467066, G571416951, An ERP Study of Infant Numerosity in Fetal Alcohol Syndrome, G5746928057, Fractionating the functions of primate ventromedial prefrontal cortex of relevance to depression., G5896455330, G6278318099, The functional role of the frontal face patches in face perception., Distributed brain systems for motivation and action, Characterising neural networks of thalamo-cortical interactions important for cognition in primates., G6732587103, G6749910122, G6868616705, G7240651115, G731561264, G734095940, G746762310, G7526101666, The functional role of dopamine in visual perceptual learning and cortical plasticity., G791781759, Functional Anatomy of Face Processing in the Primate Brain, G8246287644, Neuroethology of social decisions in primates., G8510727784, G8550219161, Co-localization and neuromodulation of interoceptive and emotional processes in the insular cortex., Human Brain Project Specific Grant Agreement 3, Neural mechanisms for foraging in an uncertain environment., G8909005302, G8924547702, Integrated neural networks in the primate brain., G9000250825, California National Primate Research Center, Visual Circuits, Human Auditory Cortex Physiology
OpenAlex ID: W3151694771