Work

Identification of a second substrate-binding site in solute-sodium symporters.

Year: 2015

Type: article

Abstract: Identification of a Second Substrate-binding Site in Solute-Sodium SymportersJournal of Biological ChemistryVol. 290Issue 1PreviewThe structure of the sodium/galactose transporter (vSGLT), a solute-sodium symporter (SSS) from Vibrio parahaemolyticus, shares a common structural fold with LeuT of the neurotransmitter-sodium symporter family. Structural alignments between LeuT and vSGLT reveal that the crystallographically identified galactose-binding site in vSGLT is located in a more extracellular location relative to the central substrate-binding site (S1) in LeuT. Our computational analyses suggest the existence of an additional galactose-binding site in vSGLT that aligns to the S1 site of LeuT. Full-Text PDF Open Access VOLUME 290 (2015) PAGES 127–141 PAGE 127: A grant was inadvertently omitted from the grant support footnote. The following grant should be included: This work was supported in part by DFG Grant JU333/4-3 from the German Research Foundation (to H. J.).

Source: Journal of Biological Chemistry

DOI: 10.1074/jbc.a114.584383