Trth-23. Feasibility and Safety of Surgical Biopsy for Patients With Dipg: Preliminary Results From Dipg-bats
Year: 2017
Type: conference-abstract
Abstract: INTRODUCTION: The DIPG Biology and Treatment Study (DIPG-BATS) incorporated a surgical biopsy at presentation and stratified patients to receive FDA-approved agents chosen on the basis of specific biologic targets. METHODS: Subjects were enrolled in the DIPG-BATS trial if the imaging appearance of the tumors had typical features of a DIPG. Surgical biopsies were performed after enrollment and prior to definitive treatment. Subjects were all treated with conventional fractionated external radiotherapy, and bevacizumab. Subjects were stratified to receive erlotinib or temozolomide, both agents, or neither agent. Whole-genome sequencing (WGS) and RNA-sequencing were performed on tumor samples but not used for treatment planning. RESULTS: Fifty-three patients were enrolled at 23 participating institutions, of which 50 underwent biopsy. The median age was 6.4 years, with a male to female ratio of 24::29. Surgical biopsies were performed using standard stereotactic techniques with a transcerebellar approach. There were no deaths attributed to the surgical procedure. Two patients experienced grade 3 toxicities during the procedure (one patient with apnea and one with hypertension). One patient experienced a neurologic deficit (left hemiparesis) that did not recover. Of the 50 patients biopsied, 46 provided sufficient tissue to perform the assays (92%, two-stage exact binomial 90% confidence interval 83–97%). CONCLUSIONS: Surgical biopsy of DIPGs is technically feasible, associated with acceptable risks, and can provide biologic data that informs treatment decision making.
Source: Neuro-Oncology
Authors: Nalin Gupta, Liliana Goumnerova, Kanya Ayyanar, William Gump, Anne Bendel, Mahmoud Nagib, Daniel Bowers, Bradley Weprin, Amy-Lee Bredlau, Sri Gururangan, Herbert Fuchs, Ken Cohen, George Jallo, Katie Dorris, Michael Handler, Melanie Comito, Mark Dias, Jason Fangusaro, Stewart Goldman, Tadanori Tomita, Tord Alden, Arthur DiPatri, Sharon Gardner, Matthias Karajannis, David Harter, Karen Gauvain, David Limbrick, Jeff Leonard, Russ Geyer, Sarah Leary, Samuel Browd, Ziad Khatib, John Ragheb, Sanjiv Bhatia, Tobey MacDonald, Dolly Aguilera, Barun Brahma, Peter Manley, Susan Chi, Sabine Mueller, Anu Banerjee, Jeff Murray, Kellie Nazemi, Lissa Baird, Nathan Robison, Erin Kiehna, Mark Krieger, Eric Sandler, Philipp Aldana, Joanne Wang, Sandeep Sood, Donna Neuberg, Maneka Puligandla, Lianne Greenspan, Karen Wright, Michael Prados, Pratiti Bandopadhayay, Keith Ligon, Mark Kieran
Institutions: University of California, San Francisco, Boston Children's Hospital, Dana-Farber Cancer Institute, University of Louisville, University of Minnesota, The University of Texas Southwestern Medical Center, Duke University, Johns Hopkins University, University of Colorado Denver, Pennsylvania State University, Northwestern University, New York University, Washington University in St. Louis, University of Washington, Miami Children's Hospital, Emory University, Cook Children's Medical Center, Oregon Health & Science University, Children's Hospital of Los Angeles, University of Florida, Children's Hospital of Michigan
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4246249982