33 – Insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) in obese paediatric patients
Year: 2012
Type: article
Study design: Observational Study
Abstract: Introduction: Insulin resistance is an important component in the development of metabolic syndrome and lifestyle-related diseases.The aim of the present study is to investigate the relationship between insulin resistance (IR), adiposity, cardiorespiratory fitness (CRF) and dietary intake among Azorean adolescents.Method: A cross-sectional school-based study, the Azorean Physical Activity and Health Study II, was conducted on 517 adolescents (297 girls) aged 15-18 years from the Azorean Islands -Portugal.We measured weight, height, BMI, waist circumference (WC), body fat mass, fasting glucose and insulin.IR was determined through homeostasis model assessment-insulin resistance (HOMA-IR).A HOMA-IR $90th percentile was considered a cardiovascular risk factor.CRF was measured with the 20-m shuttle run test.Dietary intake was obtained using a semi-quantitative FFQ.Results: 19?1 % of the whole sample had a HOMA-IR $90th percentile.There was no significant difference in IR concentration between boys (1?93 6 1?6) and girls (1?97 6 1?0; P .0?05).Pearson's correlation test for HOMA-IR and adiposity were positive and significantly (P , 0?001) associated with BMI (r 5 0?33), WC (r 5 0?31) and fat mass percentage (r 5 0?29), while a significant but negative association was found for CRF (r 5 20?15).The percentage of carbohydrate (r 5 0?16, P , 0?001) was positive and significantly associated with HOMA-IR, whereas total fat (r 5 20?15, P 5 0?001) and daily energy intake (r 5 20?15, P 5 0?001) were negative and significantly associated with HOMA-IR.Conclusions: To prevent the development of IR, reducing adiposity, increasing CRF could be effective strategies to prevent future metabolic diseases.
Source: Public Health Nutrition
Authors: PAPA, RAFFAELE EDO, GUTTADORO, DEBORAH, PIEDIMONTE, ALESSANDRA, MOSCA, ANTONELLA, MERCURIO, ROBERTA, VANIA, Andrea, A. M. Caiazzo, C. M. L'Amante, Valerio Nobili
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4246390378